Photo: Greg Fiume / Getty Images Sport / Getty Images
In the matchup between the Philadelphia Eagles and Detroit Lions on Sunday, Nov. 16 at 8:20 p.m. ET, our computer model expects the Eagles to emerge victorious. Seeking predictions on the final score, spread, and point total, too? Find a complete game projection below.
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Eagles vs. Lions Game Info and TV Channel
- When: Sunday, November 16, 2025 at 8:20 p.m. ET
- Where: Lincoln Financial Field in Philadelphia, Pennsylvania
- TV: NBC/Peacock
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on SportsRadio 94WIP
Eagles vs. Lions Odds and Betting Info
- Spread favorite: Eagles (-2.5)
- Moneyline: Eagles (-148), Lions (+124)
- Total: 46.5 points
Eagles vs. Lions Prediction
- Pick ATS: Eagles (-2.5)
- Pick OU: Over (46.5)
Prediction:
Eagles 26 - Lions 23
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Eagles vs. Lions Betting Insights
- The Eagles have put together a 6-3-0 record against the spread this season.
- The Lions have covered six times in nine matchups with a spread this year.
- When playing as at least 2.5-point favorites this season, the Eagles have an ATS record of 4-3.
- Detroit has covered the spread once this year (1-1 ATS) when playing as at least 2.5-point underdogs.
- The Eagles and their opponent have combined to go over the point total five out of nine times this season.
- So far this year, five out of the Lions' nine games with a set over/under have gone over the point total.
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