Our projection model predicts the Philadelphia Eagles will defeat the Los Angeles Rams on Sunday, Sept. 21 at 1 p.m. ET. For a complete projection on the matchup at Lincoln Financial Field, which includes our prediction on the spread, over/under, and final score, keep reading.
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Eagles vs. Rams Game Info and TV Channel
- When: Sunday, September 21, 2025 at 1 p.m. ET
- Where: Lincoln Financial Field in Philadelphia, Pennsylvania
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Eagles vs. Rams Odds and Betting Info
- Spread favorite: Eagles (-3.5)
- Moneyline: Eagles (-186), Rams (+155)
- Total: 44.5 points
Eagles vs. Rams Prediction
- Pick ATS: Eagles (-3.5)
- Pick OU: Under (44.5)
Prediction:
Eagles 28 - Rams 16
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Eagles vs. Rams Betting Insights
- The Eagles have covered once in two games with a spread this season.
- The Rams have covered twice in two games with a spread this season.
- Philadelphia has not covered the spread when favored by 3.5 points or more this season (in one opportunity).
- So far this season, none of the Eagles' games have gone over the point total.
- Games featuring the Rams have hit the over once this year.
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